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Pemphigus Vulgaris – Pathogenesis, Clinical Features, Histopathology and Treatment



Pemphigus vulgaris is an autoimmune muco-cutaneous condition occurring as a result of inappropriate production of auto-antibodies against the desmosomes holding the epithelial cells together, leading to an intra-epithelial blister formation. There is widespread ulceration of the skin, oral mucosal and other mucosal surfaces causing much pain and debilitation.

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42 Responses

  1. Hack Dentistry

    2:42 – "While desmoglein 3 is predominant in the oral mucosal epithelial junctions, desmoglein 1 is present in the EPIDERMIS"(not dermis as mentioned in video)

    3:08 – "…EPIDERMIS is affected with a superficial split, when desmoglein 1 is targeted." (not dermis as mentioned in video)

  2. Sanjay Kirwale

    My uncle is suffering from pemphigus vuglarius since 3 yrs also no. Of time treated by dermatologist but yet problem is not solved… Now half of his body infected by same… so plz help me for next.

  3. Ria Fitzgerald

    My mother in law passed away last January due to complications from Phemphus Vulgaris. She was treated in the burn unit at Vanderbilt hospital in Nashville. Horrible condition that most hospitals haven't a clue about.

  4. vagh mayuri

    Thank you so much for the explanation. it was a very helpful video. sir, Can we differentiate the Pemphigus Vulgaris and other Pemphigus types by just looking or other new techniques..?

  5. गणेश गायकवाड

    माझा पत्नी ला झालेला आहे खाणे पिणे चे पथे सांगा

  6. Safa Farooq Wani

    my aunt has p.folacious…. she's on steroid drugs as of now but her limbs are getting affected by the side effects of the drug… (they are in constant pain) and the lesions keep appearing every now and then….. can you please tell me if there is some permanent cure for it? she's so much affected… hurts to see her in this constant pain 😔

  7. Helena Tranová

    My brother suffers from an unknown skin disease he has been treating for over 2 years. The symptoms are Pemphigus vegetans, but I'm not a doctor, so I do not know for sure. My brother is currently using ointment with corticosteroids, but they only alleviate symptoms and prevent enlargement. He does not treat the disease and returns again … His life with this disease is not in direct danger, but if he stops taking the ointment, the illness would spread all over the body after a few months. Please ask what tests to ask … doctors have already taken samples several times, but none of them know what it is …. 🙁

  8. Vinoda Rao

    At 0:10 , pemphigus vulgaris is an autoimmune condition characterised by inappropriate production of autoantibodies against desmosomes???!???

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